Tuesday, 28 August 2012

Linagliptin


Pronunciation: LIN-a-GLIP-tin
Generic Name: Linagliptin
Brand Name: Tradjenta


Linagliptin is used for:

Treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.


Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body and decreasing the amount of sugar made by your body.


Do NOT use Linagliptin if:


  • you are allergic to any ingredient in Linagliptin

  • you have type 1 diabetes

  • you have high blood ketone levels (diabetic ketoacidosis)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Linagliptin:


Some medical conditions may interact with Linagliptin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of inflammation of the pancreas (pancreatitis)

  • if you are also using insulin

Some MEDICINES MAY INTERACT with Linagliptin. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Rifamycins (eg, rifampin) because they may decrease Linagliptin's effectiveness

  • Meglitinides (eg, repaglinide) or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Linagliptin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Linagliptin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Linagliptin:


Use Linagliptin as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • An extra patient leaflet is available with Linagliptin. Talk to your pharmacist if you have questions about this information.

  • Take Linagliptin by mouth with or without food.

  • Take Linagliptin on a regular schedule to get the most benefit from it.

  • Continue to take Linagliptin even if you feel well. Do not miss any doses.

  • If you miss a dose of Linagliptin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Linagliptin.



Important safety information:


  • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular blood sugar testing are important for best results with Linagliptin.

  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Linagliptin exactly as prescribed, tell your doctor.

  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.

  • Linagliptin usually does not cause low blood sugar. However, low blood sugar may occur when it is used along with certain other medicines for diabetes (eg, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.

  • Lab tests, including fasting blood glucose and hemoglobin A1c, may be performed while you use Linagliptin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Linagliptin should be used with extreme caution in CHILDREN younger than 18 years; safety and effectiveness in these children have not been confirmed.

  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Linagliptin while you are pregnant. It is not known if Linagliptin is found in breast milk. If you are or will be breast-feeding while you take Linagliptin, check with your doctor. Discuss any possible risks to your baby.


Possible side effects of Linagliptin:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Headache; joint pain; runny or stuffy nose; sore throat.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); symptoms of pancreas inflammation (eg, severe stomach or back pain with or without nausea or vomiting).



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Linagliptin side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Linagliptin:

Store Linagliptin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Linagliptin out of the reach of children and away from pets.


General information:


  • If you have any questions about Linagliptin, please talk with your doctor, pharmacist, or other health care provider.

  • Linagliptin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Linagliptin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Linagliptin resources


  • Linagliptin Side Effects (in more detail)
  • Linagliptin Dosage
  • Linagliptin Use in Pregnancy & Breastfeeding
  • Linagliptin Drug Interactions
  • Linagliptin Support Group
  • 5 Reviews for Linagliptin - Add your own review/rating


  • Linagliptin Professional Patient Advice (Wolters Kluwer)

  • linagliptin Advanced Consumer (Micromedex) - Includes Dosage Information

  • Tradjenta Prescribing Information (FDA)

  • Tradjenta Consumer Overview



Compare Linagliptin with other medications


  • Diabetes, Type 2

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