Tarceva

Pronunciation: er-LOE-ti-nib
Generic Name: Erlotinib
Brand Name: Tarceva

Tarceva is used for:

Treating certain types of advanced or metastatic lung cancer. It is also used to treat certain types of pancreatic cancer in combination with another medicine (gemcitabine).

Tarceva is a tyrosine kinase inhibitor. It works by blocking growth stimulatory signals in cancer cells, which helps stop cancer cells from growing.

Do NOT use Tarceva if:

• you are allergic to any ingredient in Tarceva

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tarceva:

Some medical conditions may interact with Tarceva. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of stomach or intestinal problems (eg, peptic ulcer, diverticular disease), liver or kidney problems, or heart or blood vessel problems


• if you have a history of lung problems (eg, lung disease or lung infection) or eye problems


• if you smoke, are dehydrated, or have a rash or another skin condition


• if you have had radiation therapy or chemotherapy

Some MEDICINES MAY INTERACT with Tarceva. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Azole antifungals (eg, itraconazole, ketoconazole, voriconazole), ciprofloxacin, HIV protease inhibitors (eg, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir), macrolide antibiotics (eg, clarithromycin), nefazodone, telithromycin, troleandomycin, or certain other medicines that act on the liver because they may increase the actions and the risk of Tarceva's side effects


• Barbiturates (eg, phenobarbital), carbamazepine, H₂ receptor antagonists (eg, ranitidine), hydantoins (eg, phenytoin), proton pump inhibitors (eg, omeprazole), rifamycins (eg, rifampin, rifabutin, rifapentine), or St. John's wort because they may decrease Tarceva's effectiveness


• Corticosteroids (eg, prednisone), NSAIDs (eg, ibuprofen), or certain other medicines because the risk of stomach or intestinal problems may be increased by Tarceva


• Anticoagulants (eg, warfarin) because the risk of bleeding may be increased by Tarceva

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tarceva may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tarceva:

Use Tarceva as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Tarceva by mouth on an empty stomach at least 1 hour before or 2 hours after eating.


• Wash your hands immediately after taking Tarceva.


• Eating grapefruit or drinking grapefruit juice while you are taking Tarceva may increase the amount of Tarceva in your blood, which may increase your risk of serious side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet.


• Take Tarceva on a regular schedule to get the most benefit from it. Taking Tarceva at the same time each day will help you to remember to take it.


• If you take an H₂ receptor antagonist (eg, ranitidine), talk with your doctor or pharmacist about how to take these medicines together.


• Do not take an antacid within 1 hour before or 2 hours after you take Tarceva.


• If you miss a dose of Tarceva, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Tarceva.

Important safety information:

• If you experience moderate to severe diarrhea or a severe skin reaction, tell your doctor right away. Your doctor may need to reduce your dose or interrupt treatment. Do not treat diarrhea with nonprescription medicines. You will need to take care not to become dehydrated. Contact your doctor for instructions.


• Check with your doctor before you smoke or use other tobacco products while using Tarceva. Tobacco products may decrease Tarceva's effectiveness.


• Women who may become pregnant should use effective birth control while they are taking Tarceva and for at least 2 weeks after treatment is complete. Check with your doctor if you have questions about effective birth control.


• Tarceva may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Tarceva may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Tarceva may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tarceva. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tell your doctor or dentist that you take Tarceva before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including liver, kidney or lung function, eye exams, or blood electrolytes, may be performed while you use Tarceva. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Tarceva with caution in the ELDERLY; they may be more sensitive to its effects.


• Tarceva should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Tarceva if you are pregnant. It has been shown to cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Tarceva is found in breast milk. Do not breast-feed while you are taking Tarceva.

Possible side effects of Tarceva:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bone pain; constipation; diarrhea; dry skin; fatigue; hair loss; loss of appetite; mild stomach pain; mouth sores or ulcers; nausea; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; chest, jaw, or left arm pain; confusion; cough; dark urine; decreased urine; excessive hair growth; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; nosebleed; numbness of arm or leg; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; severe eye dryness, irritation, pain, redness, or discharge; severe or persistent diarrhea, nausea, loss of appetite, stomach pain, or vomiting; severe rash accompanied by fever, blistering, mouth sores, swelling, muscle or joint aches, or discomfort; shortness of breath; slurred speech; sudden, severe headache; swelling of the hands, legs, or feet; unusual bruising or bleeding; unusual tiredness or weakness; vision problems or decrease in vision; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tarceva side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; rash.

Proper storage of Tarceva:

Store Tarceva at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom. Keep Tarceva out of the reach of children and away from pets.

General information:

• If you have any questions about Tarceva, please talk with your doctor, pharmacist, or other health care provider.


• Tarceva is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tarceva. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tarceva resources

• Tarceva Side Effects (in more detail)
• Tarceva Use in Pregnancy & Breastfeeding
• Drug Images
• Tarceva Drug Interactions
• Tarceva Support Group
• 11 Reviews for Tarceva - Add your own review/rating

• Tarceva Prescribing Information (FDA)


• Tarceva Consumer Overview


• Tarceva Monograph (AHFS DI)


• Tarceva Advanced Consumer (Micromedex) - Includes Dosage Information


• Erlotinib Professional Patient Advice (Wolters Kluwer)

Compare Tarceva with other medications

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Sodium Sulfacetamide and Sulfur Aqueous Gel

Dosage Form: gel
10% Sodium Sulfacetamide and Sulfur 5% Aqueous Gel (in a Urea vehicle)

Rx only

DESCRIPTION:  Sodium sulfacetamide is a sulfonamide with antibacterial activity.  Sulfur acts as a keratolytic agent.  Chemically, sodium sulfacetamide is N-[(4-aminophenyl)sulfonyl]-acetamide, monosodium salt, monohydrate. The structural formula is:

Each mL of 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) contains 100 mg of sodium sulfacetamide and 50 mg of sulfur in an emulsion base containing 10% Urea, propylene glycol, isopropyl myristate, mineral oil, polysorbate 60, sorbitan monostearate, cetyl alcohol, cocoglycerides, stearyl alcohol, benzyl alcohol, glyceryl stearate and PEG 100 stearate, dimethicone, fragrance, disodium EDTA, xanthan gum, zinc pyrithione, sodium thiosulfate, purified water, magnesium aluminum silicate, and methyl paraben.

CLINICAL PHARMACOLOGY:  The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth.  While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged.  The biological half-life has variously been reported as 7 to 12.8 hours.  The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

INDICATIONS: 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

CONTRAINDICATIONS: 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) is contraindicated for patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation.  10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) is not to be used in patients with kidney disease.

WARNINGS: Rarely, sensitivity to sodium sulfacetamide may occur. Therefore, caution and careful supervision should be observed when prescribing this drug tor patients who may be prone to hypersensitivity to topical sulfonamides. Systemic toxic reactions such as agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice, and contact dermatitis indicate hypersensitivity to sulfonamides. Use particular caution on areas of denuded or abraded skin.

FOR EXTERNAL USE ONLY. Keep away from eyes.

Keep out of reach of children. Keep tube tightly closed.

PRECAUTIONS: General - If irritation develops, use of the product should be discontinued and appropriate therapy instituted.  Patients should be carefully observed for possible local irritation or sensitization during long-term therapy.  The object of this therapy is to achieve desquamation without irritation, but sodium sulfacetamide and sulfur can cause reddening  and scaling of the epidermis.  These side effects are not unusual in the treatment of acne vulgaris, but patients should be cautioned about the possibility.

Information for Patients - Avoid contact with eyes, eyelids, lips and mucous membranes. If accidental contact occurs, rinse with water. If excessive irritation develops, discontinue use and consult your physician.

Carcinogenesis, Mutagenesis and Impairment of Fertility - Long-term studies in animals have not been performed to evaluate carcinogenic potential.

Pregnancy - Category C. Animal reproduction studies have not been conducted with 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle). It is also not known whether 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) should be given to a pregnant woman only if clearly needed.

Nursing Mothers - It is not known whether sodium sulfacetamide is excreted in human milk following topical use of 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle). However, small amounts of orally administered sulfonamides have been reported to be excreted in human milk. For this reason, and because many drugs are excreted in human milk, caution should be exercised when 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle) is administered to a nursing woman.

Pediatric Use: Safety and effectiveness in children under the age of 12 years have not been established.

ADVERSE REACTIONS: Rarely, sodium sulfacetamide may cause local irritation.

Call your physician for medical advice about side effects.

DOSAGE AND ADMINISTRATION:

10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle): Cleanse affected areas. Apply a thin film into affected areas 1 to 3 times daily, or as directed by a physician.

HOW SUPPLIED:

10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle): is available in a 1.5 fl. oz (45 g) tube, NDC 42808-0111-45

Store 10% Sodium Sulfacetamide 5% Sulfur Aqueous Gel (in a Urea vehicle): at 15 to 30°C (59 to 86°F).

Protect from freezing.

Manufactured in the U.S.A. for Exact-Rx, Inc., Melville, NY 11747

00-0111-45-205-00

Iss:6/11

PACKAGE LABEL - 1.5 oz (45 g)

For External Use Only

NDC 42808-0111-45        Rx Only

Sodium

Sulfacetamide

& Sulfur

(Sodium Sulfacetamide 10%

& Sulfur 5% in a Urea Vehicle)

10%/5%

AQUEOUS GEL

Exact-Rx.

INCORPORATED

Net Wt. 1.5 oz (45 g)

SODIUM SULFACETAMIDE, SULFUR   sodium sulfacetamide, sulfur  gel

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 42808-111 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength SULFACETAMIDE SODIUM (SULFACETAMIDE) SULFACETAMIDE SODIUM 100 mg  in 1 g SULFUR (SULFUR) SULFUR 50 mg  in 1 g

Inactive Ingredients Ingredient Name Strength UREA   PROPYLENE GLYCOL   ISOPROPYL MYRISTATE   MINERAL OIL   POLYSORBATE 60   SORBITAN MONOSTEARATE   CETYL ALCOHOL   COCO-GLYCERIDES   STEARYL ALCOHOL   BENZYL ALCOHOL   GLYCERYL MONOSTEARATE   POLYOXYL 100 STEARATE   DIMETHICONE   EDETATE DISODIUM   XANTHAN GUM   PYRITHIONE ZINC   SODIUM THIOSULFATE   WATER   MAGNESIUM ALUMINUM SILICATE   METHYLPARABEN

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 42808-111-45 1 TUBE In 1 CARTON contains a TUBE 1 45 g In 1 TUBE This package is contained within the CARTON (42808-111-45)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		08/01/2011

Labeler - Exact-Rx, Inc. (137953498)

Revised: 08/2011Exact-Rx, Inc.

More Sodium Sulfacetamide and Sulfur Aqueous Gel resources

• Sodium Sulfacetamide and Sulfur Aqueous Gel Side Effects (in more detail)
• Sodium Sulfacetamide and Sulfur Aqueous Gel Use in Pregnancy & Breastfeeding
• Sodium Sulfacetamide and Sulfur Aqueous Gel Drug Interactions
• Sodium Sulfacetamide and Sulfur Aqueous Gel Support Group
• 18 Reviews for Sodium Sulfacetamide and Sulfur Aqueous - Add your own review/rating

Compare Sodium Sulfacetamide and Sulfur Aqueous Gel with other medications

• Acne
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• Seborrheic Dermatitis

Boots Decongestant Tablets with Paracetamol

Boots Decongestant Tablets with Paracetamol

(Paracetamol, Pseudoephedrine Hydrochloride)

Read all of this leaflet carefully because it contains important information for you.

This medicine is available without prescription to treat minor conditions. However, you still need to take it carefully to get the best results from it.

• Keep this leaflet, you may need to read it again


• Ask your pharmacist if you need more information or advice

What this medicine is for

This medicine contains Paracetamol, an analgesic, which acts to relieve pain and reduce fever. It also contains Pseudoephedrine, a decongestant, which acts to relieve a blocked nose.

It can be used to relieve the symptoms of colds and flu, including aches and pains, headache, blocked nose and sinuses and to reduce fever.

For children, simple treatments should be tried first before you give this medicine. Further information on "Treating coughs and colds in children" is provided at the end of this leaflet.

Before you take this medicine

This medicine can be taken by adults and children of 6 years and over. However, some people should not take this medicine or should seek the advice of their pharmacist or doctor first.

Do not take:

• 
  If you are allergic to any of the ingredients in this medicine (see 'What is in this medicine')


• 
  If you are allergic to other decongestants
  


• 
  If you have severe liver or kidney problems
  


• 
  If you have heart or blood vessel disease, including poor circulation in your hands or feet


• 
  If you have high blood pressure (including that due to a tumour near your kidney)


• 
  If you have diabetes
  


• 
  If you have an overactive thyroid
  


• 
  If you have glaucoma or you have been told you have high pressure in the eye


• 
  If you are taking any of these medicines:
  
  • Monoamine oxidase inhibitors or moclobemide (for depression), or have taken them in the last 14 days
  
  
  • Medicines called beta-blockers (normally for heart problems)
  
  
  • Other decongestants
  
  


• 
  If you are pregnant
  

Talk to your pharmacist or doctor:

• If you have other kidney or liver problems (including a disease caused by drinking alcohol)


• If you are dependent on alcohol


• If you are a man with prostate problems


• If you are breastfeeding

Other important information

Do not drink alcohol (wine, beer, spirits) whilst taking this medicine.

If you take other medicines

This medicine contains paracetamol.

Do not take with any other paracetamol-containing products.

Before you take these tablets, make sure that you tell your pharmacist about ANY other medicines you might be using at the same time, particularly the following:

• Medicines to treat high blood pressure


• Medicines for heart problems (e.g. digoxin)


• Medicines which may cause a dry mouth (e.g. tricyclic antidepressants)


• Medicines to reduce your appetite or stimulant medicines


• Ergot alkaloids (for migraine)


• Oxytocin (to induce labour and stop excessive bleeding after the birth)


• Medicines for epilepsy


• Contraceptive tablets


• Non-steroidal anti-inflammatory drugs (for pain and swelling)


• Warfarin or other blood thinners – if you take warfarin you can take occasional amounts of this medicine, but talk to your doctor first before you take it on a regular basis

If you are unsure about interactions with any other medicines, talk to your pharmacist. This includes medicines prescribed by your doctor and medicine you have bought for yourself, including herbal and homeopathic remedies.

How to take this medicine

Check the foil is not broken before use. If it is, do not take that tablet.

Adults and children of 12 years and over

Take one tablet

3 or 4 times in 24 hours, if you need to.
Don't take more than 4 tablets in any 24 hours.

Children of 6 to 11 years

Take half a tablet

4 times in 24 hours, if you need to.
Don't take more than 4 half tablets in any 24 hours.

Don't take more often than every four hours.

Swallow the tablet with water.

Do not give to children under 6 years.

Do not take more than the amount recommended above.

If you are treating a child and their symptoms worsen at any time, talk to a pharmacist or doctor.

Do not take this medicine for more than 5 days, unless your doctor tells you to.

If symptoms do not go away talk to your doctor.

If you take too many tablets: Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage. Go to your nearest hospital casualty department. Take your medicine and this leaflet with you.

Possible side effects

Most people will not have problems, but some may get some.

If you get any of these serious side effects, stop taking the tablets. See a doctor at once:

• Difficulty in breathing, swelling of the face, neck, tongue or throat (severe allergic reactions)

If you get any of these side effects, stop taking the tablets:

• Hallucinations


• Restlessness


• Sleep disturbances

These other effects are less serious. If they bother you talk to a pharmacist:

• Other allergic reactions including skin rash


• Feeling sick, being sick


• Anxiety, feelings of paranoia, irritability, feeling excited, tremors, headache, difficulty sleeping


• Fast, slow or irregular heart beat, palpitations


• High blood pressure


• Difficulty in passing urine


• Unusual bruising or infections such as sore throats – this may be a sign of very rare changes in the blood

If any side effect becomes severe, or you notice any side effect not listed here, please tell your pharmacist or doctor.

How to store this medicine

Do not store above 30°C.

Store in the original package.

Keep this medicine in a safe place out of the sight and reach of children, preferably in a locked cupboard.

Use by the date on the foil or on the end flap of the carton. After this date return any unused product to your nearest pharmacy for safe disposal.

What is in this medicine

Each tablet contains Paracetamol 500 mg, Pseudoephedrine Hydrochloride 60 mg, which are the active ingredients.

As well as the active ingredients, the tablets also contain microcrystalline cellulose, pregelatinised maize starch, croscarmellose sodium, sodium laurilsulfate, magnesium stearate, quinoline yellow (E104).

The pack contains 12 yellow capsule shaped tablets.

Who makes this medicine

Manufactured for the Marketing Authorisation holder

The Boots Company PLC

Nottingham

NG2 3AA

by

Hamol Limited

Nottingham

NG90 2DB

Leaflet prepared May 2009

If you would like any further information about this medicine, please contact

The Boots Company PLC

Nottingham

NG2 3AA

Treating coughs and colds in children

It's normal for children to get 8 or more colds in a year, however gradually they build up immunity and get fewer colds. Most colds will get better within a few days and you may not need to do more than keep your child comfortable until they get over it. Antibiotics will not help to treat a cold as they are caused by viruses and not bacteria.

Follow these simple steps, which may help your child overcome their cough or cold:

• 
  
  1. If your child is hot or has a fever:
  Increase the amount of fluid your child normally drinks. Lower their temperature with a Paracetamol or Ibuprofen medicine, which is suitable for children. (Paracetamol is not suitable for children under 2 months. Ibuprofen is not suitable for children under 3 months).

Your pharmacist will be able to help you find a suitable product if in doubt.

• 
  
  2. For coughs:
  Although it may be distressing to hear your child cough, the coughing itself serves an important purpose. It helps to clear phlegm on the chest or mucus from the nose. Give your child plenty of lukewarm clear fluids to drink, which may help loosen the phlegm and relax the airways.
  
  


• 
  
  3. To help with breathing:
  Plain saline nose drops, available from your pharmacy, can help babies with blocked noses who are having trouble feeding.

Other formats

To request a copy of this leaflet in Braille, large print or audio please call, free of charge: 0800 198 5000 (UK only)

Please be ready to give the following information:

Product name: Boots Decongestant Tablets with Paracetamol

Reference number: PL00014/0594

This is a service provided by the Royal National Institute of Blind People.

BTC46089 vB 29/06/09

Leader Allergy Relief D-24

Generic Name: loratadine and pseudoephedrine (lor AT a deen and SOO doe ee FED rin)

Brand Names: Alavert D-12, Claritin-D, Claritin-D 24 Hour, Leader Allergy Relief D-24, Loratadine-D 24 Hour

What is Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of loratadine and pseudoephedrine is used to treat sneezing, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Loratadine and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use loratadine and pseudoephedrine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use loratadine and pseudoephedrine before the MAO inhibitor has cleared from your body. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant. This medication may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of loratadine and pseudoephedrine.

What should I discuss with my healthcare provider before taking Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

Do not use this medication if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use loratadine and pseudoephedrine before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• kidney disease;


• 
  

  glaucoma;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  diabetes;

  
  


• 
  

  thyroid disorder;

  
  


• 
  

  an enlarged prostate; or

  
  


• 
  

  problems with urination.

  
  

FDA pregnancy category B. This medication is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether loratadine and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have surgery, tell the surgeon ahead of time if you have taken a cold or allergy medicine within the past few days.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold or allergy medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

This medication may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of this medication.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Leader Allergy Relief D-24 (loratadine and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats, seizure);

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  urinating less than usual or not at all.

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, stomach pain, constipation;

  
  


• 
  

  mild loss of appetite, stomach upset;

  
  


• 
  

  warmth, redness, or tingly feeling under your skin;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  skin rash or itching;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration; or

  
  


• 
  

  mild ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Leader Allergy Relief D-24 (loratadine and pseudoephedrine)?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by loratadine. Tell your doctor if you regularly use any of these medicines, or any other cold or allergy medicine.

Tell your doctor about all other medicines you use, especially:

• 
  

  blood pressure medications;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.

  
  

This list is not complete and other drugs may interact with loratadine and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Leader Allergy Relief D-24 resources

• Leader Allergy Relief D-24 Side Effects (in more detail)
• Leader Allergy Relief D-24 Use in Pregnancy & Breastfeeding
• Leader Allergy Relief D-24 Drug Interactions
• 0 Reviews for Leader Allergy Relief D-24 - Add your own review/rating

• Claritin-D Consumer Overview


• Claritin-D 24 Hour 24-Hour Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Leader Allergy Relief D-24 with other medications

• Hay Fever
• Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about loratadine and pseudoephedrine.

See also: Leader Allergy Relief D-24 side effects (in more detail)

Biliary Tract Tumor Medications

Topics under Biliary Tract Tumor

• Biliary Obstruction (0 drugs)

• Biliary Tract and Hepatic Tumor (0 drugs)

Learn more about Biliary Tract Tumor

Medical Encyclopedia:

• Cancer
• Cholangiocarcinoma
• Hepatocellular carcinoma

Drug List:

Toradol IV/IM

Generic Name: ketorolac (Oral route, Injection route)

kee-toe-ROLE-ak

Oral route(Tablet)

For short term use only (up to 5 days in adults). Not for use in pediatric patients and not indicated for minor or chronic pain. Contraindicated in patients with peptic ulcer disease, recent GI bleeding or perforation, peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, advanced renal impairment, risk of renal failure due to volume depletion, cerebrovascular bleeding, hemorrhagic diathesis, incomplete homeostasis, high-risk of bleeding, prophylactic analgesic before major surgery, labor and delivery use, nursing mothers, and concomitant aspirin or NSAID use. Use caution with elderly patients due to high risk of GI adverse events and in patients with cardiovascular disease or risk factors. Adjust dosages for elderly patients, patients under 50 kg, and patients with moderately elevated serum creatinine .

Injection route(Solution)

For short term use only (up to 5 days in adults). Not for use in pediatric patients and not indicated for minor or chronic pain. Contraindicated in patients with peptic ulcer disease, recent GI bleeding or perforation, peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery, advanced renal impairment, risk of renal failure due to volume depletion, cerebrovascular bleeding, hemorrhagic diathesis, incomplete homeostasis, high-risk of bleeding, prophylactic analgesic before major surgery, previously demonstrated hypersensitivity reactions, intrathecal or epidural administration, labor and delivery use, nursing mothers, and concomitant aspirin or NSAID use. Use caution with elderly patients due to high risk of GI adverse events and in patients with cardiovascular disease or risk factors. Adjust dosages for elderly patients, patients under 50 kg, and patients with moderately elevated serum creatinine .

Commonly used brand name(s)

In the U.S.

• Toradol


• Toradol IV/IM

Available Dosage Forms:

• Tablet


• Solution


• Injectable

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Toradol IV/IM

Ketorolac is used to relieve moderately severe pain, usually pain that occurs after an operation or other painful procedure. It belongs to the group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Ketorolac is not a narcotic and is not habit-forming. It will not cause physical or mental dependence, as narcotics can. However, ketorolac is sometimes used together with a narcotic to provide better pain relief than either medicine used alone.

Ketorolac has side effects that can be very dangerous. The risk of having a serious side effect increases with the dose of ketorolac and with the length of treatment. Therefore, ketorolac should not be used for more than 5 days. Before using this medicine, you should discuss with your doctor the good that this medicine can do as well as the risks of using it.

Ketorolac is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, ketorolac is used in certain patients with the following medical conditions:

• Pain after surgery in children

Before Using Toradol IV/IM

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of ketorolac in children up to 16 years of age with use in other age groups.

Geriatric

Stomach or intestinal problems, swelling of the face, feet, or lower legs, or sudden decrease in the amount of urine may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of ketorolac. Also, elderly people are more likely than younger adults to get very sick if the medicine causes stomach problems. Studies in older adults have shown that ketorolac stays in the body longer than it does in younger people. Your doctor will consider this when deciding on how much ketorolac should be given for each dose and how often it should be given.

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Aceclofenac


• Acemetacin


• Alclofenac


• Apazone


• Aspirin


• Benoxaprofen


• Bufexamac


• Carprofen


• Clometacin


• Clonixin


• Dexketoprofen


• Diclofenac


• Diflunisal


• Dipyrone


• Droxicam


• Etodolac


• Etofenamate


• Felbinac


• Fenbufen


• Fenoprofen


• Fentiazac


• Floctafenine


• Flufenamic Acid


• Flurbiprofen


• Ibuprofen


• Indomethacin


• Indoprofen


• Isoxicam


• Ketoprofen


• Lornoxicam


• Meclofenamate


• Mefenamic Acid


• Meloxicam


• Nabumetone


• Naproxen


• Niflumic Acid


• Nimesulide


• Oxaprozin


• Oxyphenbutazone


• Pentoxifylline


• Phenylbutazone


• Pirazolac


• Piroxicam


• Pirprofen


• Probenecid


• Propyphenazone


• Proquazone


• Sulindac


• Suprofen


• Tenidap


• Tenoxicam


• Tiaprofenic Acid


• Tolmetin


• Zomepirac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beclamide


• Beta Glucan


• Bivalirudin


• Caramiphen


• Carbamazepine


• Certoparin


• Chlormethiazole


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Diazepam


• Dipyridamole


• Enoxaparin


• Escitalopram


• Ethotoin


• Felbamate


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Fosphenytoin


• Gabapentin


• Ginkgo


• Heparin


• Lacosamide


• Lepirudin


• Levetiracetam


• Mephenytoin


• Mephobarbital


• Methotrexate


• Nadroparin


• Nefazodone


• Oxcarbazepine


• Paraldehyde


• Paramethadione


• Parnaparin


• Paroxetine


• Pemetrexed


• Phenacemide


• Phenobarbital


• Phenytoin


• Piracetam


• Pregabalin


• Protein C


• Reviparin


• Rivaroxaban


• Rufinamide


• Sertraline


• Sibutramine


• Stiripentol


• Tacrolimus


• Tiagabine


• Ticlopidine


• Tinzaparin


• Tirofiban


• Topiramate


• Trimethadione


• Valproic Acid


• Vigabatrin


• Vilazodone


• Zimeldine


• Zonisamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse or


• Diabetes mellitus (sugar diabetes) or


• Edema (swelling of face, fingers, feet or lower legs caused by too much fluid in the body) or


• Kidney disease or


• Liver disease (severe) or


• Systemic lupus erythematosus (SLE)—The chance of serious side effects may be increased

• Asthma or


• Heart disease or


• High blood pressure—Ketorolac may make your condition worse.

• Bleeding in the brain (history of) or


• Hemophilia or other bleeding problems—Ketorolac may increase the chance of serious bleeding

• Bleeding from the stomach or intestines (history of) or


• Colitis, stomach ulcer, or other stomach or intestinal problems (or history of)—Ketorolac may make stomach or intestinal problems worse. Also, bleeding from the stomach or intestines is more likely to occur during ketorolac treatment in people with these conditions

Proper Use of ketorolac

This section provides information on the proper use of a number of products that contain ketorolac. It may not be specific to Toradol IV/IM. Please read with care.

For patients taking ketorolac tablets:

• To lessen stomach upset, ketorolac tablets should be taken with food (a meal or a snack) or with an antacid.


• Take this medicine with a full glass of water. Also, do not lie down for about 15 to 30 minutes after taking it. This helps to prevent irritation that may lead to trouble in swallowing.

For patients using ketorolac injection:

• Medicines given by injection are sometimes used at home. If you will be using ketorolac at home, your health care professional will teach you how the injections are to be given. You will also have a chance to practice giving injections. Be certain that you understand exactly how the medicine is to be injected.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for more than 5 days. Using too much of this medicine increases the chance of unwanted effects, especially in elderly patients.

Ketorolac should be used only when it is ordered by your doctor for treating certain kinds of pain. Because of the risk of serious side effects, do not save any leftover ketorolac for use in the future, and do not share it with other people.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For pain:
    
    • Adults (patients 16 years of age and older)—One 10-milligram (mg) tablet four times a day, four to six hours apart. Some people may be directed to take two tablets for the first dose only.
    
    
    • Children up to 16 years of age—Use and dose must be determined by your doctor.
    
    
  
  


• For injection dosage form:
  
  • For pain:
    
    • Adults (patients 16 years of age and older)—15 or 30 mg, injected into a muscle or a vein four times a day, at least 6 hours apart. This amount of medicine may be contained in 1 mL or in one-half (0.5) mL of the injection, depending on the strength. Some people who do not need more than one injection may receive one dose of 60 mg, injected into a muscle.
    
    
    • Children up to 16 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Toradol IV/IM

Taking certain other medicines together with ketorolac may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take every day, and on how long you take the medicines together. Therefore, do not take acetaminophen (e.g., Tylenol) together with ketorolac for more than a few days, unless otherwise directed by your medical doctor or dentist. Also, do not take any of the following medicines together with ketorolac, unless your medical doctor or dentist has directed you to do so and is following your progress:

• Aspirin or other salicylates


• Diclofenac (e.g., Voltaren®)


• Diflunisal (e.g., Dolobid®)


• Etodolac (e.g., Lodine®)


• Fenoprofen (e.g., Nalfon®)


• Floctafenine (e.g., Idarac®)


• Flurbiprofen (e.g., Ansaid®)


• Ibuprofen (e.g., Motrin®)


• Indomethacin (e.g., Indocin®)


• Ketoprofen (e.g., Orudis®)


• Meclofenamate (e.g., Meclomen®)


• Mefenamic acid (e.g., Ponstel®)


• Nabumetone (e.g., Relafen®)


• Naproxen (e.g., Naprosyn®)


• Oxaprozin (e.g., Daypro®)


• Phenylbutazone (e.g., Butazolidin®)


• Piroxicam (e.g., Feldene®)


• Sulindac (e.g., Clinoril®)


• Tenoxicam (e.g., Mobiflex®)


• Tiaprofenic acid (e.g., Surgam®)


• Tolmetin (e.g., Tolectin®)


• Zomepirac (e.g., Zomax®)

Ketorolac may cause some people to become dizzy or drowsy. If either of these side effects occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert.

Serious side effects can occur during treatment with this medicine. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, or unusual flushing or warmth of skin. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.

Toradol IV/IM Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Swelling of face, fingers, lower legs, ankles, and/or feet


• weight gain (unusual)

Less common

• Bruising (not at place of injection)


• high blood pressure


• skin rash or itching


• small, red spots on skin


• sores, ulcers, or white spots on lips or in mouth

Rare

• Abdominal or stomach pain, cramping, or burning that is severe


• bleeding from the rectum or bloody or black, tarry stools


• bloody or cloudy urine


• blue lips and fingernails


• blurred vision of other vision change


• burning, red, tender, thick, scaly, or peeling skin


• chest pain


• convulsions


• cough or hoarseness


• dark urine


• decrease in amount of urine that is sudden


• fainting


• fast, irregular, noisy, or troubled breathing


• fever with severe headache, drowsiness, confusion, and stiff neck or back


• fever with or without chills or sore throat


• hallucinations (seeing, hearing, or feeling things that are not there)


• hearing loss


• hives


• increase in amount of urine or urinating often


• light-colored stools


• loss of appetite


• low blood pressure


• mood changes or unusual behavior


• muscle cramps or pain


• nausea, heartburn, or indigestion that is severe and continues


• nosebleeds


• pain in lower back and/or side


• pain, tenderness, or swelling in the upper stomach area


• painful or difficult urination


• pale skin


• puffiness or swelling of the eyelids or eyes


• ringing or buzzing in ears


• runny nose


• severe restlessness


• shortness of breath


• swollen or painful glands


• swollen tongue


• thirst that continues


• tightness in the chest with or without wheezing


• unusual tiredness or weakness


• vomiting of blood or material that looks like coffee grounds


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain (mild or moderate)


• bruising at place of injection


• diarrhea


• dizziness


• drowsiness


• headache


• indigestion


• nausea

Less common or rare

• Bloating or gas


• burning or pain at place of injection


• constipation


• feeling of fullness in abdominal or stomach area


• increased sweating


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Toradol IV/IM side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More Toradol IV/IM resources

• Toradol IV/IM Side Effects (in more detail)
• Toradol IV/IM Use in Pregnancy & Breastfeeding
• Toradol IV/IM Drug Interactions
• Toradol IV/IM Support Group
• 1 Review for Toradol IV/IM - Add your own review/rating

• Ketorolac MedFacts Consumer Leaflet (Wolters Kluwer)


• Ketorolac Prescribing Information (FDA)


• Ketorolac Tromethamine Monograph (AHFS DI)


• Sprix Spray MedFacts Consumer Leaflet (Wolters Kluwer)


• Sprix Consumer Overview


• Toradol Prescribing Information (FDA)


• Toradol Consumer Overview

Compare Toradol IV/IM with other medications

• Pain
• Postoperative Pain

Cortisporin Cream

Pronunciation: HYE-droe-KOR-ti-sone/NEE-oh-MYE-sin/POL-ee-MIX-in
Generic Name: Hydrocortisone/Neomycin/Polymyxin B
Brand Name: Cortisporin

Cortisporin Cream is used for:

Treating inflammation (swelling, warmth, redness, pain) due to certain skin conditions when an infection is present.

Cortisporin Cream is a combination of 2 antibiotics and a corticosteroid. The antibiotics work by slowing the growth of, or killing, sensitive bacteria. The corticosteroid reduces inflammation.

Do NOT use Cortisporin Cream if:

• you are allergic to any ingredient in Cortisporin Cream, to other aminoglycosides (eg, tobramycin), or to other corticosteroids (eg, prednisone)


• you have a viral infection of the skin (eg, herpes simplex, vaccinia, chickenpox, shingles), tuberculosis of the skin, or a fungal skin infection


• you are using Cortisporin Cream on your ear and you have a perforated ear drum

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cortisporin Cream:

Some medical conditions may interact with Cortisporin Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin


• if you have had a recent vaccination; have measles or tuberculosis; or you have had a positive tuberculosis test

Some MEDICINES MAY INTERACT with Cortisporin Cream. Because little, if any, of Cortisporin Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Cortisporin Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cortisporin Cream:

Use Cortisporin Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Cortisporin Cream is for topical use only. Do not get Cortisporin Cream in your eyes. If you get Cortisporin Cream in your eyes, rinse immediately with cool tap water.


• Wash your hands before and after using Cortisporin Cream.


• Apply a small amount of medicine to the affected area. Rub in gently.


• To clear up your infection completely, use Cortisporin Cream for the full course of treatment. Keep using it even if you feel better in a few days.


• If you miss a dose of Cortisporin Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cortisporin Cream.

Important safety information:

• Cortisporin Cream only works against bacteria; it does not treat fungal or viral infections.


• Be sure to use Cortisporin Cream for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Cortisporin Cream may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Do not use Cortisporin Cream for other conditions at a later time.


• Cortisporin Cream has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Check with your doctor before having any vaccinations while you are using Cortisporin Cream.


• Cortisporin Cream should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Cortisporin Cream.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cortisporin Cream while you are pregnant. It is not known if Cortisporin Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Cortisporin Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Cortisporin Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning or peeling of the skin not present when you began using Cortisporin Cream; changes in hearing; decreased urination; excessive hair growth; inflamed hair follicles; inflammation around the mouth; loss of hearing; muscle weakness; increased or persistent pain, redness, irritation, or swelling; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face.

Proper storage of Cortisporin Cream:

Store Cortisporin Cream between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep the container tightly closed. Keep Cortisporin Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Cortisporin Cream, please talk with your doctor, pharmacist, or other health care provider.


• Cortisporin Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Cortisporin Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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