Hematogen FA Capsules

Dosage Form: capsule
Hematogen FA

Liquid - Iron in a Soft Gelcap

DESCRIPTION

CONTENTS : Each maroon and brown soft gelatin capsule contains:

Ferrous fumarate USP........................................................................200 mg

(66 mg elemental iron)

Ascorbic acid USP..............................................................................250 mg

Folic acid USP........................................................................................1 mg

Cyanocobalamin USP.........................................................................10 mcg

DISCUSSION : The amount of elemental iron and the absorption of the iron components of commercial iron preparations vary widely. It is further established that certain "accessory components" may be included to enhance absorption and utilization of iron. Hematogen FA Capsules are formulated to provide the essential factors for a complete, versatile hematinic.

ACTIONS

HIGH ELEMENTAL IRON CONTENT: Ferrous fumarate, used in Hematogen FA Capsules, is an organic iron 1,2 complex which has the highest elemental iron content of any hematinic salt - 33% This compares with 20% for ferrous sulfate (heptahydrate) and 13% for ferrous gluconate.

MORE COMPLETE ABSORPTION: It has been repeatedly shown that Ascorbic acid, when given in sufficient amounts, can increase the absorption of ferrous Iron from the gastrointestinal tract. The absorption promoting effect is mainly due to the reducing action of ascorbic acid within the gastrointestinal lumen, which helps to prevent or delay the formation of insoluble or less dissociated ferric compounds. Iron absorption has been shown to increase sharply with increasing amounts of ascorbic acid, showing a gain in absorption of approximately 40% at 250 mg. Above 250 mg, the gain becomes insignificant, with an additional gain of only approximately 8% at 500 mg. Each Hematogen FA capsule contains 250 mg of ascorbic acid, believed to be the optimal amount

PROMOTES MOVEMENT OF PLASMA IRON: Ascorbic acid also plays an important role in the movement of plasma iron to storage depots in the tissues .The action, which leads to the transport of plasma iron to ferritin, presumably involves its reducing effect, converting transferrin iron from the ferric to the ferrous state. There is also evidence that ascorbic acid improves iron utilization, presumably as a further result of its reducing action and some evidence that effect upon erythropoiesis. Ascorbic acid is further alleged to enhance the conversion of folic acid to a more physiologically active form, folinic acid, which would make it even more important in the treatment of anemia since it would aid in the utilization of dietary folic acid."

EXCELLENT ORAL TOLERATION: Ferrous fumarate is used in Hematogen FA Capsules because it is less likely to cause the gastric disturbances so often associated with oral iron therapy. Ferrous fumarate has a low ionization constant and high solubility in the entire pH range of the gastrointestinal tract. It does not precipitate proteins or have the astringency of more ionizable forms of iron, and does not interfere with proteolytic or diastatic activities of the digestive system. Because of excellent oral toleration, Hematogen FA Capsules can usually be administered between meals when iron absorption is maximal.

FOLIC ACID SUPPLEMENTATION: The use of supplemental folic acid may be indicated in patients with increased requirements for this vitamin, such as iron deficiency anemia. Folic acid administration may 12 reduce the risk of neural tube defects in the developing fetus . Folic acid has also been shown to reduce circulating homocysteine leveIs in the blood . FoIate as 5-methyltetrahydrofolate and B as  methylcobalamin are involved in the remethylation reaction of homocysteine to methionine. Elevated homocysteine plasma levels are associated with increased risk of preeclampsia, neural tube defects, myocardial infarction and artherosclerosis.

TOXICITY: Ferrous fumarate was found to be the least toxic of three popular oral iron salts, with an oral LD of 630 mg/kg. In the same report, the LD of ferrous gluconate was reported to be 320 mg/kg and ferrous sulfate 230 mg/kg.

INDICATIONS

For the treatment of all anemias responsive to oral iron therapy, such as hypochromic anemia associated with pregnancy, chronic or acute blood loss, dietary restriction, metabolic disease and post-surgical convalescence. it may have a direct only

CONTRAINDICATIONS

Hemochromatosis and hemosiderosis are contraindications to iron therapy. Folic acid is contraindicated in patients with pernicious anemia (see PRECAUTIONS).

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years of age. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

PRECAUTIONS

Folic acid should not be prescribed until the diagnosis of pernicious anemia has been eliminated, since it can 14 alleviate the hematologic manifestations, while allowing neurological damage to continue undetected.

ADVERSE REACTIONS

Average capsule doses in sensitive individuals or excessive dosage may cause nausea, skin rash, vomiting, diarrhea, precordial pain, or flushing of the face and extremities.

DOSAGE AND ADMINISTRATION

Usual adult dose is 1 soft gelatin capsule daily.

HOW SUPPLIED

Capsules NDC 63044-632-17, Unit Dose Box 100

CAUTION: Federal law prohibits dispensing without prescription.

Distributed by:                                                 Manufactured by

Nnodum Pharmaceuticals                                Banner Pharmacaps

Cincinnati, Ohio 45229                                    Olds, Canada

BIBLIOGRAPHY

'Berk, M.S. and Novich, M.A.: 'Treatment of Iron Deficiency Anemia With Ferrous Fumarate," Am. J. Obst. & Gynec., 203-206, 1962. 'Shapleigh, J.B., and Monigomery, A.:Am. Pract. & Dig. Treat. 1 Q-461 , 1959. 3 Brise, H. and Hallberg, L.: "Effect of Ascorbic Acid on Iron Absorption," Acta. Med Scand.171:376,51-58,1962. 4 ‘New Drugs, p. 309, AMA, Chicago, 1966. 5 'Mazur, A., Green, S. and Carleton, A,: "Mechanism of Plasma Iron Incorporation into Hepatic Ferritin," J. Bio. Chern. 3:595-603, 1960. 'Greenberg, S.M, Tucker, A. E., Mathues, Hand JD: "Iron Absorption and Metabolism, I. Interrelationship of Ascorbic Acid and Vitamin E," J. Nutrition 6319:31,}957 'Moore, C.V and Dubach, R "Observatiol).S"9!)tl§~rJ1~P?f Iron fromFoodsTag~edv-:ith ~ron frans. A~. f'hysic.64:~1.~, ~ ~uDac1i, R. and-MoOte, C V Studies in Iron Transportation and Metabolism, "Arch. Int. Med 95:181,1955. 'Gorten, M K. and Bradley, J E.: "The Treatment of Nutritional Anemia in Infancy and Childhood with Oral Iron and Ascorbic Acid," J Pediatrics, 45:1, 1954. ,oMazur, A.: "Role of Ascorbic Acid in the Incorporation of Plasma Iron into Ferritin," Ann. N.Y. Acad. Sci, 92:223-229, .1961. I'COX, E.V. et al.: 'The Anemia of Scurvy," Amer. J. Med 42:220-227,1967. "McEvoy, G.K., Ed.: AHFS Drug Information, p. 2667-2669, Am. Soc. Hosp. Pharm., Bethesda, 1996. '3Berenbaum, M.C. et al.: Blood, 15:540, 1960. "Dru~ Information for the Health Care Professional, p.1365-1368, U S Phar- macopeial Conven., Rockville, 1995. Franken DG, Boers GH, Blom HJ, Trijbels JM "Effect of various regi- mens of vitamin B, and folic acid on mild hyperhomocystelnemia in vascular patients." J Inherit. Metab. Dis 1994; 17:159-62. "Brattstrom L, Israeisson B, Norrving B, et al. "Impaired homocysteine metabolism in early- onset cerebral and peripheral occlusive disease - effects 01 pyridoxine and folic acid treatment." Atheroscle- rosi~ 1990; 812004-6. "Ka'1!J S. Wong PWK, NoruslS-t.x:"Homocysteinemla due_to folate deficiency." Me- tabolism~9$1!"4S8-62. ,~ BH.SI8w..-SO';Savage DG, Lindernbaum J. "Dia9nosis of cobalamin deficiency. "IL usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J. Hema- 1011990; 34 90-98. '"Dekker GA, de Vries JI, Doelitzsch PM, Huijgens PC, von Blomberg BM, Jakobs, C, van Geijn HP 1985 "Underj:ging disorder associated with severe early-onset preeclampsia." Am. J. Obstet. Gy- necol. 173: 1042-1046. Mills JL, McPartlin JM, Kirke PN, Lee Y J, Conley MR, Weir DG, Scott JM 1995. "Ho-mocysteine metabolism in pregnancies complicated by neural-tube defects." Lancet. 345: 149-151. " Steegers- Theunissen RP, Boers GH, Blom HJ, Nijhuis JG, Thomas CM, Borm GF, Eskes TK. 1995. "Neural tube defects and elevated homocysteine levels in amniotic fluid." Am. J. Obstel Gynecol172 1436-1441. "Landgren F. Is- raelsson B, Lindgren A, Hultberg B, Andersson A, Brattstrom L 1995. "Plasma homocysteine in acute my- ocardial infarction: Homocysteine-lowering effect of folic acid." J. Intern. Med. 237: 381-388. '3Mayer EL, Ja- cobsen DW, Robinson K. 1996. "Homocysteine and Coronary Atherosclerosis." J.Am. Coli. Cardiol27: 517-27.

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

HEMATOGEN FA  hematogen fa  capsule

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 63044-632 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength FERROUS FUMARATE (IRON) FERROUS FUMARATE 200 mg ASCORBIC ACID (ASCORBIC ACID) ASCORBIC ACID 250 mg FOLIC ACID (FOLIC ACID) FOLIC ACID 1 mg CYANOCOBALAMIN (CYANOCOBALAMIN) CYANOCOBALAMIN 10 ug

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color BROWN (maroon and brown) Score no score Shape CAPSULE Size 1mm Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 63044-632-17 10 BLISTER PACK In 1 BOX contains a BLISTER PACK 1 10 CAPSULE In 1 BLISTER PACK This package is contained within the BOX (63044-632-17)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
Unapproved drug other		01/01/2005

Labeler - Nnodum Pharmaceuticals (960457273)

Establishment
Name	Address	ID/FEI	Operations
BANNER PHARMACAPS		242721744	MANUFACTURE

Revised: 12/2009Nnodum Pharmaceuticals

More Hematogen FA Capsules resources

• Hematogen FA Capsules Use in Pregnancy & Breastfeeding
• Drug Images
• Hematogen FA Capsules Drug Interactions
• Hematogen FA Capsules Support Group
• 11 Reviews for Hematogen FA - Add your own review/rating

Compare Hematogen FA Capsules with other medications

• Anemia
• Vitamin/Mineral Supplementation and Deficiency

Tamoxifen 10mg, 20mg & 40mg Film-Coated Tablets

TAMOXIFEN FILM-COATED TABLETS

Please read this leaflet carefully before you start to take this medicine. It gives an outline of the more important things you should know. If you want to know more about this medicine, or you are not sure about anything, ask your doctor or pharmacist. You should keep this leaflet throughout your course of treatment.

The Name Of Your Medicine Is Tamoxifen Tablets

Tamoxifen Tablets contain the active ingredient tamoxifen citrate. The tablets come in three strengths, 10mg, 20mg and 40mg.

Other ingredients in your tablets are lactose, maize starch, pregelatinised maize starch, magnesium stearate, methylhydroxypropylcellulose, propylene glycol, Opaspray white (E171 and E464).

Tamoxifen 10mg Film-Coated Tablets are white, circular, film-coated tablets marked TAM10 on one face and CP on the reverse and contain 15.2mg of tamoxifen citrate equivalent to 10mg tamoxifen.

Tamoxifen 20mg Film-Coated Tablets are white, circular, film-coated tablets marked TAM20 on one face and CP on the reverse and contain 30.4mg of tamoxifen citrate equivalent to 20mg tamoxifen.

Tamoxifen 40mg Film-Coated Tablets are white, circular, film-coated tablets marked TAM40 on one face and CP on the reverse and contain 60.8mg of tamoxifen citrate equivalent to 40mg tamoxifen.

Tamoxifen Tablets are available in strip packs of 30 tablets.

Marketing Authorisation Holder:

Wockhardt UK Limited

Ash Road North

Wrexham

LL13 9UF

UK

Manufacturer:

CP Pharmaceuticals Limited

Ash Road North

Wrexham

LL13 9UF

UK

How Does Your Medicine Work?

Tamoxifen belongs to a group of medicines known as anti-oestrogens, which modify the effects of the female hormone, oestrogen.

What Are Tamoxifen Tablets For?

Tamoxifen is used for the treatment of breast growths and some forms of female infertility.

Before Taking This Medicine

You should not take or be given Tamoxifen Tablets if:-

• You have ever had a reaction or been told that you are allergic to tamoxifen or any of the other ingredients in the tablet. Check by reading the list of ingredients above.


• You are pregnant (you should have a pregnancy test before starting to take tamoxifen).


• You are breast-feeding or plan to breast-feed.


• You are being treated for infertility and either you or a close relative are prone to events such as strokes or pulmonary embolism (blood clot on the lung).

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

There is an increased incidence of changes associated with the lining of the womb (Endometrium), including thickening of the lining, polyps and cancer. If you notice any unusual vaginal bleeding or discharges, or any feelings of pain or tightness around the lower stomach area, contact your doctor immediately.

The risk of blood clots in veins (also called deep vein thrombosis or DVT) may be increased by taking tamoxifen. They are not usually serious, but if a clot travels to the lungs (pulmonary embolism or PE), it can cause breathlessness, chest pain, collapse or even be fatal. Both DVT and PE are often described as examples of venous thrombo-embolism (VTE).

If you get a painful swelling in your leg or sudden chest pain and difficulty breathing, talk to your doctor at once as these may be signs of blood clots in the veins or lungs.

There are several other things which raise the risk of blood clots in veins:

• If you or any of your family have had a blood clot in the veins or lungs before.


• Being elderly or very overweight.


• Being off your feet because of major surgery, illness or injury.

Talk to your doctor if any of these applies to you.

If you are going to have surgery, make sure your doctor knows about it as you may need to stop taking tamoxifen six weeks before the operation to reduce the risk of VTE.

Taking another medicine while you are taking Tamoxifen Tablets can affect how it or the other medicine works. Make sure that your doctor knows what other medicines you are taking. Do not take any other medicines while you are taking Tamoxifen Tablets unless you have told your doctor or pharmacist and asked their advice. This includes medicine you may have bought yourself.

Examples of medicines that can affect Tamoxifen Tablets are:-

• Anticoagulants (blood thinning agents) such as warfarin.


• Rifampicin, a drug used to treat tuberculosis.


• Mitomycin and aminoglutethimide, also used to treat breast cancer.

Taking This Medicine

The usual starting dose for adults for breast growths is 20mg daily. The same dosage is used in the elderly.

The usual adult dose of tamoxifen for the treatment of infertility is 20mg daily given on the second, third, fourth and fifth days of the monthly cycle. The first day of the monthly cycle is the first day of bleeding. Your doctor may increase the dose to 40mg or 80mg if further courses of treatment are thought necessary.

In patients who do not have regular periods, the treatment can be started on any day. A further course of treatment may be given 45 days later or on the second day of your period if you start bleeding.

Your doctor will decide the dose which is best for you. Always follow your doctor's instructions completely. Also follow any instructions or warnings which appear on the label which the pharmacist has put on the pack. If you do not understand or are in any doubt, ask your doctor or pharmacist.

If your medicine has been given to you in a blister pack, press on the tablet from the blister (or bubble) side, pushing it through the foil. Do not remove the tablet from the blister until you are ready to take it.

Unless told otherwise these tablets should be taken with a glass of water.

You should take these tablets for as long as your doctor tells you to. If you forget to take a dose, take another as soon as you remember. If it is almost time for your next dose, then do not take the missed dose at all. Never double the next dose to make up for the one missed. Do not stop taking the medicine without talking to your doctor first.

If you accidentally take too many Tamoxifen Tablets you should contact your doctor, pharmacist or nearest hospital casualty department immediately. Take this leaflet and any tablets that you have left to show the doctor or pharmacist.

Are There Any Side-Effects?

Like many medicines tamoxifen may occasionally cause side-effects in some patients, particularly when you first start taking it. Side-effects that some patients have experienced with tamoxifen include hot flushes, breast pain or discomfort (especially at the start of treatment), skin rash, dry skin, hair loss or thinning, itching in the genital area, stomach upsets, weight gain, swelling due to water retention, dizziness, tiredness, confusion, depression, and headache. Periods may be interrupted or stop when taking these tablets. Problems with the lining of the womb or the ovaries may cause heavy or painful periods or “spotting” between periods. There is an increased risk of cancer of the womb in patients taking high doses of tamoxifen for a long time.

There have been reports of blood disorders which may cause fever or chills, sore throats, mouth or throat ulcers, unusual tiredness or weakness, unusual bleeding or unexplained bruises. Tell your doctor if you develop any such problems. Fatty liver, inflammation of the liver, a tendency to gall stones, an increase in the level of liver enzymes or certain fats (triglycerides) in the blood and inflammation of the pancreas or lungs have also been reported.

You should consult your doctor if these side-effects are troublesome or continue.

More serious side-effects include pain, discomfort or swelling in the lower part of the abdomen, unusual vaginal bleeding or discharge, irregular periods, or hazy or blurred vision. If you get these or any other symptoms not described above, tell your doctor.

If you start feeling very sick or vomiting, or develop thirst, loss of appetite, constipation, weak muscles or confusion, tell your doctor, as this may be due to too much calcium in the blood.

You should stop taking Tamoxifen Tablets and tell your doctor IMMEDIATELY if you develop any of the following:

• swelling of the face, lips, tongue or throat.


• difficulty in swallowing or breathing.


• “hives” or nettle rash (known as urticaria).


• swelling or pain in the arms or legs (this could be due to a blood clot or thrombosis).


• pain in the chest (this could be due to a blood clot on the lung).

Also, because of the way this medicine acts on the body, there is a chance that it might cause other unwanted effects that may not occur until months or years after this medicine is used. Tamoxifen could possibly increase the chance of cancer of the uterus (womb) in some women taking it. Discuss this possible effect with your doctor.

Safe Keeping For This Medicine

• Do not take this medicine if the expiry date on the label has passed or if the tablets show signs of 'going off' such as discoloration.


• These tablets should not be stored above 25°C. Store in the original container in which they were given to you in order to protect from light and moisture. Do not transfer Tamoxifen Tablets to another container.


• 
  Keep Tamoxifen Tablets in a secure place out of the reach and sight of children.
  


• 
  Remember this medicine is for you only. Never give it to anyone else. It may harm them, even if their symptoms are the same as yours.


• Unless your doctor tells you to, do not keep tablets that you no longer need. Give them back to your pharmacist.

Other formats:

To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:

0800 198 5000 (UK Only)

Please be ready to give the following information:

Product Name: Reference Number


Tamoxifen 10mg Film-Coated Tablets: 29831/0194

Tamoxifen 20mg Film-Coated Tablets: 29831/0195

Tamoxifen 40mg Film-Coated Tablets: 29831/0196

This is a service provided by the Royal National Institute of the Blind.

Date of Revision of Leaflet

March 2007

CP5

103505/2

Panocaps

Generic Name: pancrelipase (oral) (pan kre LYE pace)

Brand Names: Cotazym, Creon, Dygase, Ku-Zyme, Ku-Zyme HP, Kutrase, Lapase, Palcaps 10, Pancrease MT 10, Pancrease MT 16, Pancrease MT 20, Pancrease MT 4, Pancrecarb MS-16, Pancrecarb MS-4, Pancrecarb MS-8, Panocaps, Panocaps MT 16, Ultrase, Ultrase MT 12, Ultrase MT 18, Ultrase MT 20, Viokase, Viokase 16, Zenpep

What is pancrelipase?

Pancrelipase is a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.

Pancrelipase is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.

Pancrelipase may also be used following surgical removal of the pancreas.

Pancrelipase may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about pancrelipase?

You should not take pancrelipase if you are allergic to pork proteins.

Before taking pancrelipase, tell your doctor if you have gout, kidney disease, a history of intestinal blockage, a sudden onset of pancreatitis, or worsening of chronic pancreatic disease.

Use pancrelipase regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not hold the tablets or capsule contents in your mouth. The medication may irritate the inside of your mouth.

Do not inhale the powder from a pancrelipase capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

If you miss a dose of this medicine, skip the missed dose and wait until your next scheduled dose to take the medicine. Do not take extra medicine to make up the missed dose.

What should I discuss with my healthcare provider before taking pancrelipase?

You should not take pancrelipase if you are allergic to pork proteins.

If you have any of these other conditions, you may need a pancrelipase dose adjustment or special tests:

• kidney disease;


• 
  

  gout;

  
  


• 
  

  a history of blockage in your intestines;

  
  


• 
  

  a sudden onset of pancreatitis; or

  
  


• 
  

  worsening of chronic pancreatic disease.

  
  

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether pancrelipase passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take pancrelipase?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Pancrelipase should be taken with a meal or snack. Take the medicine with a full glass of water or juice.

Do not hold the tablets or capsule contents in your mouth. The medication may irritate the inside of your mouth.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

You may open the pancrelipase capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

Do not inhale the powder from a pancrelipase capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Use pancrelipase regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store in the original container at room temperature (below 78 degrees F) for up to 12 weeks. Protect from moisture or high heat. Keep the bottle tightly closed when not in use. If the medication is exposed to temperatures between 78 and 104 degrees F, throw it away after 30 days. Do not use any pancrelipase that has been exposed to temperatures above 104 degrees F.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include diarrhea or stomach upset.

What should I avoid while taking pancrelipase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Pancrelipase side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe or unusual stomach pain. This could be a symptom of a rare but serious bowel disorder.

Less serious side effects may include:

• 
  

  nausea or vomiting;

  
  


• 
  

  mild stomach pain or upset;

  
  


• 
  

  diarrhea or constipation;

  
  


• 
  

  bloating or gas.

  
  


• 
  

  greasy stools;

  
  


• 
  

  rectal irritation;

  
  


• 
  

  headache, dizziness;

  
  


• 
  

  cough; or

  
  


• 
  

  weight loss.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pancrelipase?

There may be other drugs that can interact with pancrelipase. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Panocaps resources

• Panocaps Side Effects (in more detail)
• Panocaps Use in Pregnancy & Breastfeeding
• Panocaps Drug Interactions
• Panocaps Support Group
• 0 Reviews for Panocaps - Add your own review/rating

• Panocaps Advanced Consumer (Micromedex) - Includes Dosage Information


• Pancrelipase Monograph (AHFS DI)


• Pancrelipase Prescribing Information (FDA)


• Pancrelipase Professional Patient Advice (Wolters Kluwer)


• Pancrelipase MedFacts Consumer Leaflet (Wolters Kluwer)


• Creon Prescribing Information (FDA)


• Creon MedFacts Consumer Leaflet (Wolters Kluwer)


• Creon Consumer Overview


• Creon 10 Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Dygase MedFacts Consumer Leaflet (Wolters Kluwer)


• Pancreaze Consumer Overview


• Pancreaze Prescribing Information (FDA)


• Zenpep Prescribing Information (FDA)


• Zenpep Consumer Overview

Compare Panocaps with other medications

• Chronic Pancreatitis
• Cystic Fibrosis
• Pancreatic Exocrine Dysfunction

Where can I get more information?

• Your pharmacist can provide more information about pancrelipase.

See also: Panocaps side effects (in more detail)

Fungoid Kit

Generic Name: miconazole topical (my CON a zole)

Brand Names: Aloe Vesta, Aloe Vesta 2 in 1 Antifungal, Baza, Cruex Prescription Strength, Desenex Prescription Strength, Fungoid, Fungoid Kit, Micatin, Micatin Cooling Action, Micatin Foot Powder, Micatin Foot Powder Deodorant, Micatin Jock Itch, Micatin Liquid Foot, Mitrazol, Monistat Derm, Ony-Clear, Zeasorb-AF

What is Fungoid Kit (miconazole topical)?

Miconazole topical is an antifungal medication. Miconazole topical prevents fungus from growing on your skin.

Miconazole topical is used to treat skin infections such as athlete's foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections.

Miconazole topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Fungoid Kit (miconazole topical)?

Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Do not use bandages or dressings that do not allow air to circulate to the affected area (occlusive dressings) unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).

Avoid getting this medication in your eyes, nose, or mouth.

Who should not use Fungoid Kit (miconazole topical)?

Do not use miconazole topical if you have had an allergic reaction to it in the past.

It is not known whether miconazole topical will harm an unborn baby. Do not use miconazole topical without first talking to your doctor if you are pregnant. It is not known whether miconazole passes into breast milk. Do not use miconazole topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Fungoid Kit (miconazole topical)?

Use miconazole topical exactly as directed by your doctor or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.

Clean and dry the affected area. Apply the cream, lotion, spray, or powder once or twice daily as directed for 2 to 4 weeks.

Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

If the infection does not clear up in 2 weeks (or 4 weeks for athlete's foot), or if it appears to get worse, see your doctor.

Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing.

Avoid getting this medication in your eyes, nose, or mouth. Store miconazole topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the dose you missed and apply only the regular amount of miconazole topical. Do not use a double dose unless otherwise directed by your doctor.

What happens if I overdose?

An overdose of miconazole topical is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that miconazole topical has been ingested, contact an emergency room or a poison control center.

What should I avoid while using Fungoid Kit (miconazole topical)?

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Fungoid Kit (miconazole topical) side effects

Serious side effects of miconazole topical use are not expected. Stop using miconazole topical and see your doctor if you experience unusual or severe blistering, itching, redness, peeling, dryness, or irritation of the skin.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fungoid Kit (miconazole topical)?

Avoid using other topicals at the same time unless your doctor approves. Other skin medications may affect the absorption or effectiveness of miconazole topical.

More Fungoid Kit resources

• Fungoid Kit Side Effects (in more detail)
• Fungoid Kit Use in Pregnancy & Breastfeeding
• Fungoid Kit Drug Interactions
• Fungoid Kit Support Group
• 0 Reviews for Fungoid - Add your own review/rating

• Baza Antifungal Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Cruex Prescription Strength Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Lotrimin AF Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Micatin Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Monistat 3 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Monistat 3 Prescribing Information (FDA)


• Monistat 7 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Zeasorb-AF Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Fungoid Kit with other medications

• Cutaneous Candidiasis
• Tinea Corporis
• Tinea Cruris
• Tinea Pedis
• Tinea Versicolor

Where can I get more information?

• Your pharmacist has additional information about miconazole topical written for health professionals that you may read.

See also: Fungoid side effects (in more detail)

Cedax

Generic Name: ceftibuten (Oral route)

sef-ti-BUE-ten

Commonly used brand name(s)

In the U.S.

• Cedax

Available Dosage Forms:

• Capsule


• Powder for Suspension

Therapeutic Class: Antibiotic

Pharmacologic Class: 3rd Generation Cephalosporin

Uses For Cedax

Ceftibuten is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Cedax

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ceftibuten in children. However, safety and efficacy have not been established in infants younger than 6 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftibuten in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving ceftibuten.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Colitis (inflammation in gut), history of or


• Diarrhea, severe, history of—Use with caution. May make these conditions worse.

• Diabetes—The oral liquid form of this medicine contains sucrose (table sugar), which can make this condition worse.

• Kidney disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

Proper Use of Cedax

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take the oral liquid at least 2 hours before or 1 hour after a meal.

Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (capsules or suspension):
  
  • For infections:
    
    • Adults and teenagers—400 milligrams (mg) once a day for 10 days.
    
    
    • Infants and children 6 months up to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 9 milligrams (mg) per kilogram (kg) of body weight per day taken for 10 days.
    
    
    • Infants up to 6 months of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the capsules in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Throw away any unused medicine after 14 days.

Precautions While Using Cedax

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Ceftibuten may cause diarrhea, and in some cases it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you or your child have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Cedax Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Burning while urinating


• confusion


• decreased urination


• difficult or labored breathing


• difficult or painful urination


• dizziness


• dry mouth


• fainting


• fever


• increase in heart rate


• lightheadedness


• rapid breathing


• shortness of breath


• sunken eyes


• thirst


• tightness in the chest


• unusual tiredness or weakness


• wheezing


• wrinkled skin

Incidence not known

• Abdominal or stomach cramps or tenderness


• back, leg, or stomach pains


• bleeding gums


• blistering, peeling, or loosening of the skin


• bloating


• bloody or cloudy urine


• bloody, black, or tarry stools


• chest pain


• chills


• clay-colored stools


• cloudy urine


• cough or hoarseness


• coughing up blood


• dark urine


• decrease in urine output or decrease in urine-concentrating ability


• diarrhea


• diarrhea, watery and severe, which may also be bloody


• difficulty with breathing or swallowing


• fast heartbeat


• feeling of discomfort


• feeling that others are watching you or controlling your behavior


• feeling that others can hear your thoughts


• feeling, seeing, or hearing things that are not there


• fever with or without chills


• general body swelling


• general feeling of tiredness or weakness


• high fever


• hives


• increased menstrual flow or vaginal bleeding


• increased thirst


• inflammation of the joints


• itching


• joint or muscle pain


• loss of appetite


• lower back or side pain


• muscle aches


• nausea or vomiting


• noisy breathing


• nosebleeds


• pain


• pale skin


• paralysis


• problems with speech or speaking


• prolonged bleeding from cuts


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red or black, tarry stools


• red or dark brown urine


• red skin lesions, often with a purple center


• red, irritated eyes


• seizures


• severe mood or mental changes


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• sudden decrease in the amount of urine


• swollen lymph glands


• swollen or painful glands


• unpleasant breath odor


• unusual behavior


• unusual bleeding or bruising


• unusual weight loss


• vomiting of blood


• wheezing


• yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• belching


• heartburn


• indigestion


• loose stools


• stomach discomfort, upset, or pain

Rare

• Agitation


• bad, unusual, or unpleasant (after) taste


• bloated, full feeling


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• change in taste


• constipation


• cracks in the skin at the corners of the mouth


• dry mouth


• excess air or gas in the stomach or intestines


• feeling unusually cold


• full feeling


• headache


• hives or welts


• increase in the body movements


• irritability


• itching of the vagina or genital area


• pain during sexual intercourse


• passing gas


• redness of the skin


• shivering


• sleepiness or unusual drowsiness


• sleeplessness


• soreness or redness around the fingernails and toenails


• stuffy nose


• thick, white vaginal discharge with no odor or with a mild odor


• trouble with sleeping


• unable to sleep


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cedax side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cedax resources

• Cedax Side Effects (in more detail)
• Cedax Use in Pregnancy & Breastfeeding
• Drug Images
• Cedax Drug Interactions
• Cedax Support Group
• 3 Reviews for Cedax - Add your own review/rating

• Cedax Prescribing Information (FDA)


• Cedax MedFacts Consumer Leaflet (Wolters Kluwer)


• Cedax Concise Consumer Information (Cerner Multum)


• Cedax Monograph (AHFS DI)


• Ceftibuten Professional Patient Advice (Wolters Kluwer)

Compare Cedax with other medications

• Bladder Infection
• Bronchitis
• Otitis Media
• Pneumonia
• Sinusitis
• Strep Throat
• Tonsillitis/Pharyngitis

Isicom

Isicom may be available in the countries listed below.

Ingredient matches for Isicom

Carbidopa

Carbidopa monohydrate (a derivative of Carbidopa) is reported as an ingredient of Isicom in the following countries:

• Czech Republic


• Germany


• Romania


• Slovakia

Levodopa

Levodopa is reported as an ingredient of Isicom in the following countries:

• Czech Republic


• Germany


• Romania


• Slovakia

International Drug Name Search

paraldehyde Oral, Injection, Rectal

par-AL-de-hyde

Available Dosage Forms:

• Solution


• Liquid


• Injectable

Therapeutic Class: Nonbarbiturate Hypnotic

Uses For paraldehyde

Paraldehyde is used to treat certain convulsive disorders. It also has been used in the treatment of alcoholism and in the treatment of nervous and mental conditions to calm or relax patients who are nervous or tense and to produce sleep. However, paraldehyde has generally been replaced by safer and more effective medicines for the treatment of alcoholism and in the treatment of nervous and mental conditions.

paraldehyde is available only with your doctor's prescription.

Before Using paraldehyde

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For paraldehyde, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to paraldehyde or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of paraldehyde in children with use in other age groups, paraldehyde is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of paraldehyde in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking paraldehyde, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using paraldehyde with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Disulfiram

Using paraldehyde with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Fospropofol


• Ketorolac


• Naproxen

Using paraldehyde with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ginkgo

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of paraldehyde. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Drug abuse or dependence (or history of)—Dependence on paraldehyde may develop

• Colitis—Paraldehyde used rectally may make the condition worse

• Emphysema, asthma, bronchitis, or other chronic lung disease, or


• Liver disease—Higher blood levels of paraldehyde may occur, increasing the chance of side effects

• Gastroenteritis (stomach flu) or


• Stomach ulcer—Paraldehyde taken by mouth may make the condition worse

Proper Use of paraldehyde

Use paraldehyde only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. If too much is used, the medicine may become habit-forming.

Do not use if liquid turns brownish in color or if it has a strong vinegar-like odor, since this means the paraldehyde is breaking down. If you have any questions about this, check with your health care professional.

For patients taking paraldehyde by mouth:

• Do not use a plastic spoon, plastic glass, or any other plastic container to take paraldehyde, since paraldehyde may react with the plastic. Use a metal spoon or glass container.


• Take paraldehyde mixed in a glass of milk or iced fruit juice to improve the taste and odor and to lessen stomach upset.

For patients using paraldehyde rectally:

• Do not use paraldehyde in any plastic container since it may react with the plastic.


• Before using paraldehyde rectally, make sure you understand exactly how to use it. Paraldehyde may need to be diluted. If you have any questions about this, check with your health care professional.

Keep paraldehyde away from the eyes and avoid getting it on the skin and clothing.

Keep paraldehyde away from heat, open flame, and sparks.

Dosing

The dose of paraldehyde will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of paraldehyde. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral and rectal dosage forms (liquid):
  
  • Adults: Dose must be determined by your doctor.
  
  
  • Children: Dose is based on body weight, and must be determined by the doctor.
  
  


• For injection dosage form:
  
  • Adults: Dose must be determined by your doctor. It will be injected into a muscle or a vein.
  
  
  • Children: Dose is based on body weight, and must be determined by the doctor.
  
  

Missed Dose

If you miss a dose of paraldehyde, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using paraldehyde

If you will be using paraldehyde regularly for a long time:

• Your doctor should check your progress at regular visits.


• Do not stop using it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are using before stopping completely.

paraldehyde will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using paraldehyde.

Before you have any medical tests, tell the medical doctor in charge that you are taking paraldehyde. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by paraldehyde.

If you think you or someone else may have taken an overdose of paraldehyde, get emergency help at once. Taking an overdose of paraldehyde or taking alcohol or other CNS depressants with paraldehyde may lead to unconsciousness and possibly death. Some signs of an overdose are confusion, muscle tremors, nausea or vomiting (continuing or severe), severe stomach cramps, severe weakness, shortness of breath or slow or troubled breathing, and slow heartbeat.

paraldehyde may cause some people to become drowsy or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to paraldehyde before you drive, use machines, or do anything else that could be dangerous if you are not alert.

paraldehyde Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Coughing (with injection only)


• skin rash

Less common

• Redness, swelling, or pain at injection site

With long-term use

• Yellow eyes or skin

Symptoms of overdose

• Cloudy urine


• confusion


• decreased urination


• fast and deep breathing


• muscle tremors


• nausea or vomiting (continuing or severe)


• nervousness, restlessness, or irritability


• shortness of breath or slow or troubled breathing


• slow heartbeat


• stomach cramps (severe)


• weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness


• nausea or vomiting (when taken by mouth)


• stomach pain (when taken by mouth)


• unpleasant breath odor

Less common

• Clumsiness or unsteadiness


• dizziness


• ``hangover'' effect

After you stop using paraldehyde, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Convulsions (seizures)


• hallucinations (seeing, hearing, or feeling things that are not there)


• increased sweating


• muscle cramps


• nausea and vomiting


• stomach cramps


• trembling

Paraldehyde will cause your breath to have a strong unpleasant odor. This effect will last until about one day after you have stopped using paraldehyde.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More paraldehyde Oral, Injection, Rectal resources

• Paraldehyde Oral, Injection, Rectal Drug Interactions
• Paraldehyde Oral, Injection, Rectal Support Group
• 0 Reviews · Be the first to review/rate this drug

Iodo-Vit

Iodo-Vit may be available in the countries listed below.

Ingredient matches for Iodo-Vit

Povidone Iodine

Povidone-Iodine is reported as an ingredient of Iodo-Vit in the following countries:

• Israel

International Drug Name Search

Cinryze

Generic Name: complement C1 esterase inhibitor (KOM ple ment C1 ES ter ase in HIB it or)

Brand Names: Berinert, Cinryze

What is complement C1 esterase inhibitor?

Complement C1 esterase inhibitor is a man-made form of a protein that occurs naturally in the blood stream and helps control inflammation in the body. In people with hereditary angioedema, complement C1 esterase inhibitor does not function properly or occurs in low levels.

Complement C1 esterase inhibitor is used in people with hereditary angioedema. The Berinert brand of this medication is used to treat attacks of angioedema. The Cinryze brand is used to prevent attacks of angioedema.

Complement C1 esterase inhibitor may also be used for purposes not listed in this medication guide.

What is the most important information I should know about complement C1 esterase inhibitor?

You should not use this medication if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.

Before you receive complement C1 esterase inhibitor, tell your doctor if you have a history of stroke or blood clot.

Do not give this medication to a child without medical advice.

You may be shown how to use Cinryze in an IV at home. This medication comes with patient instructions for safe and effective use. Follow all directions carefully. Ask your doctor or pharmacist if you have any questions.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Be sure you understand how to properly mix and store the medication. Stop your IV infusion and get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat.

Other serious side effects may include sudden numbness or weakness, chest pain, confusion, pain or swelling, and problems with vision, speech, or balance.

Complement C1 esterase inhibitor is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

What should I discuss with my health care provider before using complement C1 esterase inhibitor?

You should not use this medication if have ever had a life-threatening allergic reaction to rugae.

To make sure you can safely use complement C1 esterase inhibitor, tell your doctor if you have a history of stroke or blood clot.

FDA pregnancy category C. It is not known whether complement C1 esterase inhibitor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether complement C1 esterase inhibitor passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Complement C1 esterase inhibitor is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication. Do not give this medication to a child without medical advice.

How should I use complement C1 esterase inhibitor?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Complement C1 esterase inhibitor is injected into a vein through an IV. A healthcare provider will give you a Berinert injection in a clinic or hospital setting. You may be shown how to use Cinryze in an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

This medication comes with patient instructions for safe and effective use. Ask your doctor or pharmacist if you have any questions.

Complement C1 esterase inhibitor is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using Cinryze home, you will need to use two vials of Cinryze to make up a single dose. Follow all directions carefully. Be sure you understand how to properly mix and store the medicine.

Gently swirl but do not shake the mixed medicine or you may ruin it. Prepare your dose only when you are ready to give yourself an injection.

Mixed Berinert should be clear and colorless. Mixed Cinryze should be clear or slightly blue in color. Do not use the mixed medicine if it has changed colors, is cloudy, or has any particles in it. Call your doctor for a new prescription.

Cinryze is usually given every 3 or 4 days to prevent angioedema attacks. An IV infusion takes about 10 minutes to complete.

Complement C1 esterase inhibitor contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.

Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Store the unmixed dry powder in a refrigerator or in a dark cool place. Keep the medicine protected from light and do not allow it to freeze. Throw away any unused vial after the expiration date on the label has passed. After mixing Berinert with the diluent, use it right away or store the mixture at room temperature and use it within 8 hours. After mixing Cinryze with the diluent, use it right away or store the mixture at room temperature and use it within 3 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden headache, numbness, weakness, or problems with your speech, vision, or balance.

What should I avoid while using complement C1 esterase inhibitor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Complement C1 esterase inhibitor side effects

Stop your IV infusion and get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any other serious side effect, such as:

• 
  

  new or worsening pain;

  
  


• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden severe headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  stomach pain or swelling;

  
  


• 
  

  chest pain, sudden cough, rapid breathing, fast heart rate; or

  
  


• 
  

  pain, swelling, warmth, or redness in one or both legs.

  
  

Less serious side effects may include:

• 
  

  nausea, vomiting, stomach pain;

  
  


• 
  

  altered sense of taste;

  
  


• 
  

  cold symptoms such as stuffy nose, sneezing, sore throat;

  
  


• 
  

  mild itching or rash; or

  
  


• 
  

  mild headache.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect complement C1 esterase inhibitor?

There may be other drugs that can interact with this medication. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Cinryze resources

• Cinryze Side Effects (in more detail)
• Cinryze Use in Pregnancy & Breastfeeding
• Cinryze Support Group
• 3 Reviews for Cinryze - Add your own review/rating

• Cinryze Monograph (AHFS DI)


• Cinryze Prescribing Information (FDA)


• Cinryze Advanced Consumer (Micromedex) - Includes Dosage Information


• Cinryze MedFacts Consumer Leaflet (Wolters Kluwer)


• Cinryze Consumer Overview


• Berinert Prescribing Information (FDA)


• Berinert MedFacts Consumer Leaflet (Wolters Kluwer)


• Berinert Consumer Overview

Compare Cinryze with other medications

• Hereditary Angioedema

Where can I get more information?

• Your doctor or pharmacist can provide more information about complement C1 esterase inhibitor.

See also: Cinryze side effects (in more detail)

Feldene

Generic Name: piroxicam (peer OX i kam)

Brand Names: Feldene

What is Feldene (piroxicam)?

Piroxicam is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body.

Piroxicam is used to treat pain or inflammation caused by arthritis.

Piroxicam may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Feldene (piroxicam)?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use piroxicam. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking piroxicam. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to piroxicam (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking piroxicam. Alcohol can increase the risk of stomach bleeding caused by piroxicam. Avoid exposure to sunlight or artificial UV rays. Piroxicam can make your skin more sensitive to sunlight and sunburn may result.

What should I discuss with my healthcare provider before taking Feldene (piroxicam)?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to piroxicam, or if you have a history of allergic reaction to aspirin or other NSAIDs.

Before taking piroxicam, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  a history of heart attack, stroke, or blood clot;

  
  


• 
  

  heart disease, congestive heart failure, high blood pressure;

  
  


• 
  

  a history of stomach ulcers or bleeding;

  
  


• liver or kidney disease;


• 
  

  asthma;

  
  


• 
  

  polyps in your nose;

  
  


• 
  

  a bleeding or blood clotting disorder; or

  
  


• 
  

  if you smoke.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take piroxicam.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking piroxicam during the last 3 months of pregnancy may harm the unborn baby. Do not take piroxicam during pregnancy unless your doctor has told you to. Piroxicam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take Feldene (piroxicam)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you switch brands of piroxicam, your dose needs may change. Follow your doctor's instructions about how much medicine to take.

If you take piroxicam for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve. Store piroxicam at room temperature away from moisture and heat.

See also: Feldene dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What should I avoid while taking Feldene (piroxicam)?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to piroxicam (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking piroxicam. Alcohol can increase the risk of stomach bleeding caused by piroxicam. Avoid prolonged exposure to sunlight. Piroxicam may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Feldene (piroxicam) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking piroxicam and seek medical attention or call your doctor at once if you have any of these serious side effects:

• 
  

  chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

  
  


• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  swelling or rapid weight gain;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


• 
  

  fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  
  


• 
  

  bruising, severe tingling, numbness, pain, muscle weakness; or

  
  


• 
  

  fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

  
  

Less serious side effects may include:

• 
  

  upset stomach, mild heartburn or stomach pain, diarrhea, constipation;

  
  


• 
  

  bloating, gas;

  
  


• 
  

  dizziness, headache, nervousness;

  
  


• 
  

  skin itching or rash;

  
  


• 
  

  blurred vision; or

  
  


• 
  

  ringing in your ears.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Feldene (piroxicam)?

Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with piroxicam may cause you to bruise or bleed easily.

Before taking piroxicam, tell your doctor if you are taking any of the following drugs:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  diuretics (water pills) such as furosemide (Lasix);

  
  


• 
  

  steroids (prednisone and others);

  
  


• 
  

  aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), and others; or

  
  


• 
  

  an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.

  
  

This list is not complete and there may be other drugs that can interact with piroxicam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Feldene resources

• Feldene Side Effects (in more detail)
• Feldene Dosage
• Feldene Use in Pregnancy & Breastfeeding
• Drug Images
• Feldene Drug Interactions
• Feldene Support Group
• 10 Reviews for Feldene - Add your own review/rating

• Feldene Prescribing Information (FDA)


• Feldene MedFacts Consumer Leaflet (Wolters Kluwer)


• Feldene Monograph (AHFS DI)


• Feldene Advanced Consumer (Micromedex) - Includes Dosage Information


• Piroxicam Prescribing Information (FDA)


• Piroxicam Professional Patient Advice (Wolters Kluwer)

Compare Feldene with other medications

• Frozen Shoulder
• Osteoarthritis
• Pain
• Rheumatoid Arthritis
• Temporomandibular Joint Disorder

Where can I get more information?

• Your pharmacist can provide more information about piroxicam.

See also: Feldene side effects (in more detail)